发明名称 METHOD FOR INDUCING TWIN CALVING
摘要 The present invention provides a method for inducing twin calving. The method according to the present invention comprises firstly treatment to inducing atresia of the antral follicles on ovary so as to initiate the development of new follicular wave, inducing the development of codominant follicles and further achieving double ovulations by exactly controlling the dosage and time points of hormone injections, and performing artificial insemination to induce the cow to deliver twin calves. The method according to the present invention has relative independent on the technical skills, and a person skilled in the art or a common worker can practice it according to specified operation methods; and during practical application, it does not require special equipment, thus saving cost, as well as improving the social benefit and economic benefit of cow breeding.
申请公布号 US2014349934(A1) 申请公布日期 2014.11.27
申请号 US201414285541 申请日期 2014.05.22
申请人 China Agricultural University 发明人 TIAN Jianhui;ZENG Weibin;AN Lei;WANG Shumin;WU Zhonghong
分类号 A61K38/24;A61K31/566;A61K31/557;A61K31/57 主分类号 A61K38/24
代理机构 代理人
主权项 1. A method for inducing a cow to produce two calves, comprising: on day 0 of the treatment, inserting an intravaginal progesterone releasing device into a cow and injecting progestin and estrogen so as to cause the follicular atresia and initiate the development of new follicular wave; on day 4.5-6, injecting follicle-stimulating hormone (FSH) in 4 times at 10-14 h intervals with sequential injection dosages of 5.5-6.5 U/cow, 5.5-6.5 U/cow, 4.5-5.5 U/cow and 4.5-5.5 U/cow, leading to the development of codominant follicle in the new follicular wave; on day 6.5-7.5, injecting estrogen to inhibit the secretion of FSH through a negative feedback, so as to inhibit non-dominant follicles from further developing; on day 8, removing the intravaginal progesterone releasing device and injecting estrogen to induce dominant follicle ovulate; on day 9.5-10, performing artificial insemination (AI).
地址 Beijing CN