发明名称 |
High affinity human antibodies to PCSK9 |
摘要 |
Abstract An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements. |
申请公布号 |
AU2014262171(A1) |
申请公布日期 |
2014.11.27 |
申请号 |
AU20140262171 |
申请日期 |
2014.11.11 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
SLEEMAN, MARK W.;MARTIN, JOEL H.;HUANG, TAMMY T.;MACDONALD, DOUGLAS |
分类号 |
C07K16/40;A61K39/395;A61P3/06;C12N9/64 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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