发明名称 |
STABLE PEPTIDE MIMETICS OF THE HIV-1 GP41 PRE-HAIRPIN INTERMEDIATE |
摘要 |
<p>The present invention relates to a gp41 trivalent peptide mimetic having three gp41 N-peptides on a chemical scaffold which conformationally constrains the N-peptides into a trimeric coiled-coil to mimic gp41 presentation. The present invention also relates to N-peptides having the entire HIV gp41 NH2-terminal heptad repeat region and which are capable of forming gp41 peptide mimetics. Such peptide mimetics of HIV-1 gp41 pre-hairpin intermediates can be utilized in a vaccine for the treatment or prevention of HIV-1 infection through eliciting neutralizing antibodies.</p> |
申请公布号 |
KR20140135771(A) |
申请公布日期 |
2014.11.26 |
申请号 |
KR20147026212 |
申请日期 |
2013.03.15 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
JOYCE JOSEPH G.;WU CHENGWEI;OTTINGER ELIZABETH A.;GARSKY VICTOR |
分类号 |
C07K14/16;A61K39/21;C12N7/00;G01N33/53 |
主分类号 |
C07K14/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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