Inhibitors of RNR2 subunit of ribonucleotide reductase to impair reverse transcription of hiv related lentiviruses in macrophages and use thereof for the treatment of hiv infected patients

摘要

The invention relates to the use of inhibitors for the RNR2 subunit of the human ribonucleotide reductase to impair reverse transcription of HIV related lentiviruses in macrophages through down regulation of the intracellular dNTPs pool by repressing expression of RNR2. The invention also concerns a method of screening inhibitors of reverse transcription of HIV related lentiviruses in macrophages.