发明名称 |
17-HYDROXYPROGESTERONE ESTER-CONTAINING ORAL COMPOSITIONS AND RELATED METHODS |
摘要 |
The present invention provides for bioavailable oral dosage forms containing esters of 17-hydroxyprogesterone as well as related methods. The oral dosage forms can be formulated for pregnancy support and can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. In another embodiment, a pharmaceutically acceptable oral dosage form for pregnancy support is provided. The pharmaceutically acceptable oral dosage can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. The oral dosage form can, when measured using a USP Type-II dissolution apparatus in 900 mL of deionized water with 0.5 (w/v) of sodium lauryl sulfate at 50 RPM at 37° C., release at least 20 wt % of the dose of the ester of 17-hydroxyprogesterone after 60 minutes, or in the alternative release at least 20 wt % more after 60 minutes than an equivalently dosed oral dosage form without the carrier. |
申请公布号 |
ZA201401464(B) |
申请公布日期 |
2014.11.26 |
申请号 |
ZA20140001464 |
申请日期 |
2014.02.26 |
申请人 |
LIPOCINE INC. |
发明人 |
GILIYAR,CHANDRASHEKAR;VENKATESHWARAN,SRINIVANSAN;CHICKMATH,BASAWARAJ,;NACHAEGARI,SATISH KUMAR;NACHIAPPAN,CHIDAMBARAM,;PATEL,MAHESH V |
分类号 |
A61K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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