发明名称 |
METHOD FOR SELECTIVELY CONTROLLING FUNCTION OF HELPER T CELL |
摘要 |
The present invention relates to selectively controlling the function of a helper T cell. In the present invention, a mouse lacking a gene involved in ganglioside biosynthesis (ganglioside GM3 synthetase gene) (SAT-I KO) was produced and analyzed. As a result, the present invention provides, for example, a method for screening a substance which induces selective suppression of the function of a helper T cell in an immune response, including control of production of a sphingoglycolipid in the helper T cell, and moderation or suppression of an excessive immune response caused by the suppression of the function, that is, a substance having an immunosuppression activity, an anti-asthmatic action and/or an anti-allergic action. |
申请公布号 |
EP2363148(B1) |
申请公布日期 |
2014.11.26 |
申请号 |
EP20090823694 |
申请日期 |
2009.10.30 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
INOKUCHI, JINICHI;NAGAFUKU, MASAKAZU;OHNO, ISAO;OKUYAMA, KAORI |
分类号 |
A61K31/7032;A01K67/027;A61K31/7105;C12N9/10;C12N15/85;G01N33/50 |
主分类号 |
A61K31/7032 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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