发明名称 |
CYCLIN A1-TARGETED T-CELL IMMUNOTHERAPY FOR CANCER. |
摘要 |
<p>Compositions and methods are provided for eliciting antigen-specific T-cell responses against human cyclin A1 (CCNA1), which is herein identified as a leukemia-associated antigen based on its overexpression in acute myeloid leukemia (AML) including leukemia stem cells (LSC) and in immunologically privileged testis cells, but not in other normal cell types. CCNA1-derived peptide epitopes that are immunogenic for T-cells including CTL are disclosed, as are immunotherapeutic approaches using such peptides for vaccines and generation of adoptive transfer therapeutic cells.</p> |
申请公布号 |
MX2014005633(A) |
申请公布日期 |
2014.11.26 |
申请号 |
MX20140005633 |
申请日期 |
2012.11.09 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
PHILIP GREENBERG;SEBASTIAN OCHSENREITHER |
分类号 |
C07K7/06;A61K38/08;A61K38/10;A61P35/00;C07K7/08;C12N5/10;C12N15/12 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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