发明名称 |
BRIDGED BICYCLIC RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE |
摘要 |
<p>The present invention is directed to synthetic bridged bicyclic compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. The method comprises administering to a subject a therapeutically effective amount of a Rho kinase inhibitory compound of Formula I, wherein said amount is effective to influence the actomyosin interactions, for example, by leading to cellular relaxation and alterations in cell-substratum adhesions. In one embodiment, the method treats increased intraocular pressure, such as primary open-angle glaucoma. In another embodiment, the method treats diseases or conditions of the lung associated with excessive cell proliferation, remodeling, inflammation, vasoconstriction, bronchoconstriction, airway hyperreactivity and edema.</p> |
申请公布号 |
EP2512239(A4) |
申请公布日期 |
2014.11.26 |
申请号 |
EP20100838164 |
申请日期 |
2010.12.10 |
申请人 |
INSPIRE PHARMACEUTICALS, INC. |
发明人 |
LAMPE, JOHN, W.;WATSON, PAUL, S.;SLADE, DAVID, J. |
分类号 |
C07D451/04;A61K31/416;A61K31/439;A61K31/4709;A61K31/55;A61P11/06;A61P11/14;A61P27/02;A61P27/06;C07D401/12;C07D403/12;C07D413/12;C07D453/06;C07D471/08;C07D487/08 |
主分类号 |
C07D451/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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