发明名称 |
N-METHANOCARBA DERIVATIVES TO TREAT CARDIAC DISEASES |
摘要 |
<p>Disclosed herein are N-methanocarba derivatives of AMP and their use in the treatment of cardiac and vascular diseases and conditions responsive to activation of the cardiac P2X receptor. In one embodiment, the N-methanocarba derivative of AMP is the N-methanocarba derivative of 2-chloro-AMP. Diseases and conditions responsive to activation of the cardiac P2X receptor include, for example, cardiac hypertrophy, cardiac failure resulting from any cause of abnormal Ca2+ homeostasis or from myocardial injuries, vascular insufficiency leading to myocardial infarction, post-myocardial infarction conditions, post-myocardial infarction conditions within the short-term post-infarction period, and diastolic heart failure.</p> |
申请公布号 |
EP2049127(B1) |
申请公布日期 |
2014.11.26 |
申请号 |
EP20070777211 |
申请日期 |
2007.05.22 |
申请人 |
UNIVERSITY OF CONNECTICUT |
发明人 |
LIANG, BRUCE, TSAN;PAPPANO, ACHILLES;SHEN, JIAN-BING |
分类号 |
A61K31/7076;A61K31/00;A61K31/138;A61P9/04;A61P9/10 |
主分类号 |
A61K31/7076 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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