发明名称 |
OPTIMIZED VACCINES TO PROVIDE PROTECTION AGAINST EBOLA AND OTHER VIRUSES |
摘要 |
<p>The invention is related to a nucleic acid molecule comprising a polynucleotide encoding a modified filovirus glycoprotein (GP) having at least one amino acid change located in a relatively conserved region of said GP that decreases in vitro cytotoxicity and retains immunogenicity when compared to in vitro cytotoxicity and immunogenicity of a wild type filovirus GP, and related modified filovirus GPs, plasmid DNAs, recombinant viruses, adenoviruses, pharmaceutical compositions, vaccine compositions, antibodies that are specifically reactive with the modified filovirus GPs, and related methods of making and using the same.</p> |
申请公布号 |
EP1797113(B1) |
申请公布日期 |
2014.11.26 |
申请号 |
EP20050813769 |
申请日期 |
2005.09.27 |
申请人 |
GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;CRUCELL HOLLAND B.V. |
发明人 |
SULLIVAN, NANCY;CHAKRABARTI, BIMAL;YANG, ZHI-YONG;PAU, MARIA GRAZIA;GOUDSMIT, JAAP;NABEL, GARY J. |
分类号 |
C07K14/08;A61K39/12;C07K16/10;C12N15/861 |
主分类号 |
C07K14/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|