Compositions and methods for detecting various disorders with targeted microbubbles are disclosed. Specifically, microbubbles comprising glycoprotein Ib (GPIb), ligands for VCAM-1, and ligands for P-selectin such as PSGL-1 are disclosed. Also disclosed are methods for using targeted microbubbles to detect cardiovascular disease comprising administering the disclosed microbubbles to a subject and detecting the microbubbles in the vasculature using ultrasound.
申请公布号
EP2148662(A4)
申请公布日期
2014.11.26
申请号
EP20080746265
申请日期
2008.04.18
申请人
OREGON HEALTH & SCIENCE UNIVERSITY
发明人
LINDNER, JONATHAN, R.;KAUFMANN, BEAT;MCCARTY, OWEN, J., T.