发明名称 |
BACILLUS, HYALURONIC ACID ENZYME, AND USES THEREOF |
摘要 |
The present invention provides a bacillus sp. having a deposit access number of CGMCC NO. 5744 and a hyaluronidase produced by the bacillus and the amino acid sequence of the hyaluronidase is shown in SEQ ID NO: 2. The present invention further relates to a process for preparing oligomeric hyaluronic acid or salts thereof or low-molecular-weight hyaluronic acid or salts thereof by using the bacillus or the hyaluronidase produced thereby. The produced oligomeric hyaluronates or low-molecular-weight hyaluronates have advantages such as good transdermal absorption ability, high purity, no cytotoxicity, potent antioxidant ability. The present invention also provides use of the bacillus having a deposit access number of CGMCC NO. 5744, or the hyaluronidase, oligomeric hyaluronates or salts thereof, low-molecular-weight hyaluronates or salts thereof produced by the bacillus in the fields of osmetics, food products and medicines. |
申请公布号 |
KR20140135210(A) |
申请公布日期 |
2014.11.25 |
申请号 |
KR20147026162 |
申请日期 |
2012.11.29 |
申请人 |
BLOOMAGE FREDA BIOPHARM CO., LTD. |
发明人 |
GUO XUEPING;SHI YANLI;QIAO LIPING;FENG NING;WANG GUANFENG;LI HAINA;XUE WEI;WANG HAIYING;LUAN YIHONG;LIU AIHUA |
分类号 |
C12N1/20;A61K8/73;A61K31/728;A61P9/00;A61P17/02;A61Q17/00;C07K14/32;C12N9/26;C12N15/56;C12P19/04;C12P19/28 |
主分类号 |
C12N1/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|