Process for preparing N-H or N-alkyl 2-propynamide

摘要

Disclosed is a method for the synthesis of N—H or N-alkyl 2-propynamides useful as intermediate in the manufacture of pharmaceutically active ingredients.

主权项

1. A method of preparing N—H or N-alkyl 2-propynamides of formula (I) wherein R1 is hydrogen or C1-4-alkyl, said process comprising reacting a propiolic acid ester of formula (II) wherein R2 is C1-2-alkyl, with an amine of the formula (III) wherein R1 is defined as in formula (I), in water, and at a reaction temperature from of about −10° C. to about 10° C. to form a compound of formula (I).