发明名称 S1P receptor modulating agent
摘要 An object of the present invention is to provide a compound having a modulating activity at an S1P receptor which is useful for preventing and treating autoimmune diseases, allergic diseases, and the like. According to the present invention, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof is provided.;
申请公布号 US8895753(B2) 申请公布日期 2014.11.25
申请号 US201213723900 申请日期 2012.12.21
申请人 Meiji Seika Pharma Co., Ltd. 发明人 Yoshida Satoshi;Ninomiya Tomohisa
分类号 C07D417/10;C07D417/14 主分类号 C07D417/10
代理机构 Wenderoth, Lind & Ponack, L.L.P. 代理人 Wenderoth, Lind & Ponack, L.L.P.
主权项 1. A compound represented by the following formula (I): wherein A represents a 4- to 7-membered cyclic amine; m represents an integer of 0 to 5; n represents an integer of 1 to 3; p represents an integer of 1 to 3; q represents an integer of 0 to 4; R1 represents C1-10 alkyl, C1-10 alkoxy, phenyl, phenoxy, phenyl C1-3 alkyloxy, a halogen atom, halogeno C1-3 alkyl, or cyano (when m is 2 or more, R1 may be each independently identical or different); R2 represents COOH, COOR6, CONR7R8, or tetrazolyl (when n is 2 or more, R2 may be each independently identical or different); R3 represents a hydrogen atom or C1-6 alkyl; R4 represents a hydrogen atom or C1-6 alkyl; or R3 and R4 may together form an oxo group (when p is 2 or more, R3 and R4 may be each independently identical or different); R5 represents C1-6 alkyl, C1-6 alkoxy, a halogen atom, halogeno C1-3 alkyl, cyano, hydroxyl, or amino (when q is 2 or more, R5 may be each independently identical or different); R6 represents C1-10 alkyl; and R7 and R8 each independently represent a hydrogen atom or C1-10 alkyl, or a pharmaceutically acceptable salt thereof.
地址 Tokyo JP