High energy radiation insensitive analyte sensors

摘要

Enzyme based analyte sensors having radiation stabilizing agents are disclosed and described. More particularly, devices comprising a radiation stabilizing agent and methods for stabilizing sensors to high energy radiation sterilization are disclosed and described.

主权项

1. An enzyme-based analyte sensor comprising at least one enzyme and at least one non-fugitive radiation stabilizing agent
wherein the radiation stabilizing agent comprises at least one of a hindered amine light stabilizer, a polymeric hindered phenol, a polymeric aromatic amine, a polymer with thioester or phosphorous containing appendages, a polymeric hydroxyl amine, a polymeric benzofuranone derivative, and polymeric acrylated bis-phenol, wherein the molecular weight of the radiation stabilizing agent is greater than about 1000 Daltons and the radiation stabilizing agent is present in an amount sufficient to stabilize the activity of the at least one enzyme when the sensor is subjected to high energy radiation.