Acrylamide compounds and the use thereof

摘要

The invention relates to acrylamide compounds of Formula I mentioned below. The invention is also directed to the use compounds of Formula I to treat or prevent a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.;

主权项

1. A compound having Formula I:a pharmaceutically acceptable salt or a solvate thereof, wherein: R1 and R2 are each independently hydrogen, cyano, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted alkenyloxy, optionally substituted alkoxycarbonyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted cycloalkyloxy, optionally substituted cycloalkenyloxy, optionally substituted aryloxy, or optionally substituted heterocyclyloxy, or R1and R2 together with the adjacent nitrogen atom form an optionally substituted ring; R3 and R4 are each independently hydrogen, halogen, optionally substituted alkyl or optionally substituted alkoxy; W is —C(R5)(R6)— or —O—; R5 and R6 are each independently hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, carboxy, alkoxycarbonyl, carbamoyl or alkylcarbamoyl; Y is —S(O)2—; Z is optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl; R is alkyl, hydroxyalkyl, alkoxyalkyl, carboxy, alkoxycarbonyl, carbamoyl or alkylcarbamoyl; m is 0 or 1; n is 1 or 2; and p is 0, 1, or 2, excluding compounds wherein Q is (B) and R2 is N-containing heterocyclyl substituted by fluoronaphtylmethyl.