| 发明名称 |
Methods for suppressing toll-like receptor activity |
| 摘要 |
Agents interfering with translocation of Toll-like receptor 3 (TLR3), methods of making and using the foregoing are disclosed. |
| 申请公布号 |
US8895263(B2) |
申请公布日期 |
2014.11.25 |
| 申请号 |
US200912572338 |
申请日期 |
2009.10.02 |
| 申请人 |
Janssen Biotech, Inc. |
发明人 |
Jordan Jarrat;Jung Sun-Yung;Sarisky Robert T.;Schreiter Jessica |
| 分类号 |
C07H21/04;C07K14/435;C07K14/705;C12N5/07;C12P21/02;A61K38/17;C07K16/28;A61K39/00 |
主分类号 |
C07H21/04 |
| 代理机构 |
|
代理人 |
Baumeister Kirk |
| 主权项 |
1. A method of interfering with translocation of toll-like receptor 3 (TLR3) in vitro, comprising transfecting into a cell expressing TLR3 a cDNA that encodes an agent that interferes with translocation of TLR3, wherein the agent is a TLR3 variant comprising a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2. |
| 地址 |
Horsham PA US |
