Starch derivative mixtures

摘要

The invention relates to a compound, comprising
a) a first starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyl alkyl starch, ester starch and arbitrary mixtures thereof, wherein the starch derivative has a mean relative molar mass Mw1 and a degree of molar substitution MS1, andb) a second starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyl alkyl starch, ester starch and arbitrary mixtures thereof, having a mean relative molar mass Mw2 and a degree of molar substitution MS2, characterized in that Mw1 is greater than Mw2 (Mw1>Mw2) and MS2 is greater than MS1 (MS2>MS1).

主权项

1. A pharmaceutical formulation comprising
a) a composition comprising
i) a first starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyalkyl starch, ester starch and any mixtures thereof, the first starch derivative having an average molecular weight Mw1 and a molar substitution MS1; andii) a second starch derivative selected from the group consisting of hydroxyalkyl starch, carboxyalkyl starch, ester starch and any mixtures thereof, with an average molecular weight Mw2 and a molar substitution MS2;wherein Mw1 is greater than Mw2 (Mw1>Mw2), and MS2 is greater than MS1 (MS2>MS1), wherein the weight ratio of the first starch derivative to the second starch derivative is from 1:9 to 9:1, and wherein the second starch derivative has an average molecular weight Mw2 from 30,000 to 80,000 daltons; and b) one or more electrolytes selected from the group consisting of sodium chloride, potassium chloride, magnesium acetate and magnesium chloride.