Antisense modulation of fibroblast growth factor receptor 4 expression

摘要

Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 4 (FGFR4). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding fibroblast growth factor receptor 4. Methods of using these compounds for modulation of fibroblast growth factor receptor 4 expression and for treatment of diseases associated with expression of fibroblast growth factor receptor 4 are provided.

主权项

1. A compound comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides and having a nucleobase sequence comprising a portion which consists of at least 12 contiguous nucleobases complementary to an equal-length portion of nucleotides 254-273, 278-297, 289-308, 289-323, 278-308, 304-323, 278-323, 289-373, 278-373, 354-373, 380-399, 412-431, 475-494, 412-494, 483-502, 475-502, 529-548, 597-616, 602-621, 597-621, 627-646, 711-730, 727-746, 739-758, 757-776, 711-746, 711-758, 711-776, 727-746, 727-758, 739-758, 727-776, 739-776, 757-776, 785-804, 833-852, 785-852, 833-983, 964-983, 785-983, 833-988, 785-988, 969-988, 964-988, 1027-1046, 1032-1051, 1027-1051, 1076-1096, 1090-1109, 1095-1114, 1076-1109, 1076-1114, 1090-1114, 1121-1040, 1181-1200, 1121-1200, 1121-1226, 1181-1226, 1235-1345, 1428-1447, 1447-1466, 1428-1466, 1452-1471, 1428-1471, 1555-1574, 1607-1626, 1656-1675, 155-1626, 1607-1675, 1555-1675, 1326-1675, 1741-1760, 1772-1791, 1919-1938, 1968-1987, 1979-1998, 1968-1998, 2268-2287, 2313-2332, 2394-2413, 2481-2500, 2497-2516, 2503-2522, 2557-2576, 2565-2584, 2629-2648, 2738-2757, 2752-2771, 2497-2584, 2738-2870, 2497-2870, or 2313-2413 of SEQ ID NO: 5, and wherein the nucleobase sequence of the modified oligonucleotide is at least 95% complementary to SEQ ID NO: 5.