| 发明名称 | Modified human tumor necrosis factor receptor-I polypeptide or fragment thereof, and method for preparing same | ||
| 摘要 | The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide which is capable of binding to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibit improved binding affinity to the tumor necrosis factor. | ||
| 申请公布号 | US8895500(B2) | 申请公布日期 | 2014.11.25 |
| 申请号 | US201113822775 | 申请日期 | 2011.09.07 |
| 申请人 | Hanall Biopharma Co., Ltd. | 发明人 | Kim Sung Wuk;Jun Sung Soo;Park Seung Kook;Kim Song Young;Kim Eun Sun;Jeong Jae Kap;Kim Ha Na;Song Yeon Jung |
| 分类号 | C07K14/705;C07K14/525;C12N15/63;A61K38/19;C07K14/715;A61K38/00 | 主分类号 | C07K14/705 |
| 代理机构 | Hultquist, PLLC | 代理人 | Hultquist, PLLC ;Hultquist Steven J.;Grant Mary B. |
| 主权项 | 1. A modified human tumor necrosis factor receptor-I (TNFRI) polypeptide or fragment thereof comprising an amino acid sequence selected from the group consisting of: i) the amino acid sequence of natural TNFRI as set forth in SEQ ID NO: 1; ii) the amino acid sequence composed of amino acid residues 41 to 211 of the amino acid sequence of the natural TNFRI set forth in SEQ ID NO: 1 (TNFRI171); iii) the amino acid sequence composed of amino acid residues 41 to 166 of the amino acid sequence of the natural TNFRI set forth in SEQ ID NO: 1 (TNFRI126); and iv) the amino acid sequence composed of amino acid residues 41 to 145 of the amino acid sequence of the natural TNFRI set forth in SEQ ID NO: 1 (TNFRI105); wherein the amino acid sequence is modified at least at positions 92, 95, 97 and 98. | ||
| 地址 | Daejeon KR | ||