Process for the separation of enantiomers of 3,6-dihydro-1,3,5-triazine derivatives

摘要

Method for the chromatographic separation of compounds of the formula (I), in which R1, R2, R3, R4, R5, R6 have the meanings indicated in Claim 1, and acid-addition salts thereof, characterized in that the separation is carried out on a chiral ion-exchanger material.

主权项

1. A method for the chromatographic separation of the enantiomers of a compound of the formula I or an acid-addition salt thereof, wherein said separation of the enantiomers is carried out on a chiral ion exchanger materialwherein
R1 and R2 are A; R3 and R4 are H; R5 is H, R6 is A, A is unbranched or branched alkyl having 1-10 C atoms, wherein 1-7 H atoms may be replaced by F, or cyclic alkyl having 3-7 C atoms; and comprising separating the enantiomers on a chiral ion exchanger which is a) of the structure below wherein X is a counterion determined by the type of buffer salt in the mobile phase and the sphere represents a support, b) of the structure below where the sphere represents a support: or c) contains one of the following structures, a spacer and a support,