Hepatic artery nerve modulation methods

摘要

According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

主权项

1. A method of facilitating hepatic neuromodulation, comprising:
inserting an energy delivery device within vasculature of a subject; intravascularly advancing a distal portion of the energy delivery device to a location within a portion of a hepatic artery; and delivering energy toward one or more nerves within or surrounding a wall of the hepatic artery sufficient to ablate the one or more nerves in a manner that facilitates a reduction in at least one of a blood glucose level or a lipoprotein level in the subject; and removing the energy delivery device from the subject.