发明名称 |
HISTIDINE ENGINEERED LIGHT CHAIN ANTIBODIES AND GENETICALLY MODIFIED NON-HUMAN ANIMALS FOR GENERATING THE SAME |
摘要 |
A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses a single light chain variable domain derived from a single rearranged light chain variable region gene in the germline of the non-human animal, wherein the single rearranged light chain variable region gene comprises a substitution of at least one non-histidine encoding codon with a histidine encoding codon. Methods of making non-human animals that express antibodies comprising a histidine-containing universal light chain are provided. |
申请公布号 |
KR20140135193(A) |
申请公布日期 |
2014.11.25 |
申请号 |
KR20147025407 |
申请日期 |
2013.03.15 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
MCWHIRTER JOHN;MACDONALD LYNN;MURPHY ANDREW J. |
分类号 |
A01K67/027;C07K16/00;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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