Systems, devices and methods for imaging and surgery

摘要

Provided herein are devices, systems and methods for imaging of biological tissue. Also provided are devices, systems and methods for surgical manipulation of biological tissue. Further provided are devices, systems and methods for combined imaging and surgical manipulation of biological tissue.

主权项

1. A system for surgical manipulation of biological tissue in a subject, comprising:
an ultra-fast pulsed surgical laser light source configured to produce laser light with pulse energies sufficient for ablation of biological tissue, wherein the pulse energies are 50 nanojoules (nJ) or higher and wherein the ultra-fast pulsed surgical laser light has a pulse duration of less than one nanosecond; an air core optical delivery fiber having a core size; a focusing lens coupling the laser light having pulse energies sufficient for ablation of biological tissue with pulse energies of 50 nJ or higher and a pulse duration of less than one nanosecond from the light source to the optical delivery fiber; wherein the coupled laser light is guided in a single mode in the optical delivery fiber; wherein a focused beam size of the laser light from the laser light source coupled to the optical delivery fiber is smaller than the core size; and an objective lens having a numerical aperture (NA) for focusing light to a given spot in the tissue, wherein the optical delivery fiber is configured to direct the coupled laser light from the surgical laser light source for transmission to the objective lens, and wherein the objective lens having the NA is configured to focus the coupled laser light to the given spot in the tissue, the energy per unit of area within the spot where the laser light is focused being sufficient for ablation of biological tissue at the focus spot.