发明名称 |
Method for preparing cefmenoxime hydrochloride compound |
摘要 |
A novel process for purifying Cefmenoxime hydrochloride comprises: 1) adding a solvent wherein Cefmenoxime hydrochloride is insoluble at the temperature less than 30° C., filtering after vigorous stirring, washing the filter cake with a solvent wherein Cefmenoxime hydrochloride is insoluble at a temperature less 20° C., and drying; 2) placing the filter cake into ammonium hydroxide, controlling the pH value less than 9 with a gentle agitation to obtain Cefmenoxime acid solution in ammonium hydroxide, and then filtering out the precipitate; 3) adding hydrochloric acid at a concentration of 0.5-4 mol/L to Cefmenoxime acid solution in ammonium hydroxide slowly and controlling the temperature between 30-60° C. and the final pH between 0.5-3.0, and then cooling down to a minimum of 10° C. and standing still to allow crystallization, filtrating and vacuum drying. |
申请公布号 |
US8895728(B2) |
申请公布日期 |
2014.11.25 |
申请号 |
US201114008542 |
申请日期 |
2011.08.11 |
申请人 |
Hainan Lingkang Pharmaceutical Co., Ltd. |
发明人 |
Tao Linggang |
分类号 |
C07D513/00;C07D501/57;C07D501/00 |
主分类号 |
C07D513/00 |
代理机构 |
CBM Patent Consulting, LLC |
代理人 |
CBM Patent Consulting, LLC |
主权项 |
1. A novel process for purifying Cefmenoxime hydrochloride of the following formula, characterized in that the process comprises: step 1) adding a solvent wherein Cefmenoxime hydrochloride is insoluble to the raw Cefmenoxime hydrochloride while controlling the temperature at the range between 10 and 30° C., filtering after vigorous stirring, washing the filter cake with a solvent wherein Cefmenoxime hydrochloride is insoluble at a temperature between 0 and 20° C., and drying in vacuum or in the air; step 2) placing the filter cake into ammonium hydroxide, controlling the pH value between 7 and 9 with a gentle agitation to obtain Cefmenoxime acid solution in ammonium hydroxide, and then filtering out the precipitate; step 3) adding hydrochloric acid at a concentration of 0.5-4 mol/L to the Cefmenoxime acid solution in ammonium hydroxide and controlling the temperature between 30° C. and 60° C., and the final pH between 0.5 and 3.0 in 30 minutes to 5 hours, and then cooling down to 10° C. and standing still to allow crystallization, filtrating and vacuum drying to obtain the refined Cefmenoxime hydrochloride; and step 4) optionally, recycling the remaining liquid of step 3) for the recrystallization in step 3). |
地址 |
Hainan CN |