发明名称 |
Multivalent pneumococcal polysaccharide-protein conjugate composition |
摘要 |
An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. |
申请公布号 |
US8895024(B2) |
申请公布日期 |
2014.11.25 |
申请号 |
US200912357853 |
申请日期 |
2009.01.22 |
申请人 |
Wyeth LLC |
发明人 |
Hausdorff William P.;Siber George Rainer;Paradiso Peter R. |
分类号 |
A61K39/385;A61K39/09;A61K39/39;A61K39/116;A61K47/48;A61K39/00 |
主分类号 |
A61K39/385 |
代理机构 |
|
代理人 |
Molenda Victoria S. |
主权项 |
1. A multivalent immunogenic composition comprising 13 distinct polysaccharide-protein conjugates and a physiologically acceptable vehicle, wherein each of the conjugates comprises a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to a carrier protein, wherein the serotypes consist essentially of 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, and wherein the carrier protein is CRM197. |
地址 |
Madison NJ US |