| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to oligosaccharide carrier conjugates effective for treating and preventing infectious diseases and containing an oligosaccharide conjugated with the carrier through a linker of formulasVIIIaorVIIIb:wherein n is more than 1, m is specified in 1-10, p is specified in 1-20 and R represents H or alkyl; the linker is bound to an oligosaccharide oxygen atom through a terminal CHgroup, and the linker is bound through a terminal CO group with an amino group of the carrier compound by an amide bond; the oligosaccharide is ?-1-6 related glucosamine, and the carrier is peptide, protein, polysaccharide, nucleic acid, lipid or tetanus toxoid.EFFECT: there are presented new conjugates effective to stimulate the immune response, and a method for preparing them.21 cl, 12 ex, 23 dwg, 1 tbl |
