ADHESIVE MIXTURE FOR TRANSDERMAL DELIVERY OF HIGHLY PLASTICIZING DRUGS

摘要

Transdermal drug delivery patches and methods of their production are described. The patches can be made such that they accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.

主权项

1. A method of producing a transdermal therapeutic adhesive formulation including at least one highly plasticizing drug comprising the steps of:
providing between about 65% and about 97%, by weight, of an acrylic polymeric adhesive which includes between about 40% and about 90% of a C4-C12 alkyl acrylate, between about 10% and about 40% by weight of a C1-C3 alkyl acrylate hardening monomer; between about 1% and about 20% by weight of a functionalizing monomer which facilitates crosslinking; and a crosslinking agent; mixing said acrylic polymeric adhesive with a highly plasticizing drug in an amount which is sufficient to provide between about 3% and about 35% of said drug by weight based on the weight of the mixture when said transdermal therapeutic adhesive formulation is dry; and crosslinking said acrylic polymeric adhesive to form a matrix capable of controlling the release of said highly plasticizing drug.