发明名称 METHODS OF TREATMENT USING ARYLCYCLOPROPYLAMINE COMPOUNDS
摘要 Described herein are methods of treating breast cancer using arylcyclopropylamine compounds.
申请公布号 US2014343118(A1) 申请公布日期 2014.11.20
申请号 US201414210848 申请日期 2014.03.14
申请人 Duke University 发明人 McCafferty Dewey G.;Hwang Sunhee;Pollock Julie A.;Gooden David M.
分类号 C07C217/74;A61K31/135;C07C211/40;A61K31/381;A61K31/145;C07D317/58;A61K31/36;C07D333/20;A61K45/06;C07C323/31 主分类号 C07C217/74
代理机构 代理人
主权项 1. A method of treating breast cancer in a subject in need of treatment, comprising administering to the subject an effective amount of a compound of formula (I): wherein R1, R2, R3, R4 and R5 are independently selected from hydrogen, C1-7 alkyl, C3-20 heterocyclyl, C5-20 aryl, C1-7 alkoxy, C1-7 haloalkyl, halo, amino, cyano, nitro, ether and thioether, or any two of R1, R2, R3, R4 and R5 may be taken together with the carbon atoms to which they are attached to form an optionally substituted ring; and R6 is selected from hydrogen and optionally substituted C5-20 aryl; or an isomer, prodrug or pharmaceutically acceptable salt thereof.
地址 Durham NC US