| 主权项 |
1. A compound of Formula I, or a pharmaceutically acceptable salt, enantiomer, stereoisomer or tautomer thereof, wherein: A is wherein the “*” is connected to the R1-substituted phenyl ring and the “#” is connected to the amide carbonyl; W is —(CH2)n-pyrazole optionally substituted with —(R3)q; X1 is halogen or C1-C6 alkyl; X2 is halogen or C1-C6 alkyl; each R1 is individually and independently halogen, H, C1-C6 alkyl, C3-C8 branched alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, branched C3-C6 alkoxy, or cyano; each R2 is individually and independently C1-C6 alkoxy, C1-C6 alkylamino, H, halogen, C1-C6 alkyl, C3-C8 branched alkyl, C3-C8 cycloalkyl, branched C3-C6 alkoxy, branched C3-C6 alkylamino, or cyano; each R3 is individually and independently C1-C6 alkyl, branched C3-C8 alkyl, halogen, —(CH2)r—CN, —(CH2)r—OR6, —(CH2)r—NR6(R7), —(CH2)r—SO2—C1-C6-alkyl, —(CH2)r—C(O)NR6(R7), —(CH2)r—C(O)—C4-C6-heterocyclyl, or —(CH2)r—C4-C6-heterocyclyl, wherein each alkyl or alkylene is optionally substituted with one or two C1-C6 alkyl; Z1 is CR4 or N; Z2 is CR5 or N; with the proviso that only one of Z1 and Z2 are simultaneously N; R4 and R5 are independently and independently H, halogen, C1-C6 alkyl, C3-C8 branched alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, branched C3-C6 alkoxy, or cyano; each R6 and R7 is individually and independently H, C1-C6 alkyl, or branched C3-C8 alkyl; m is 0, 1, or 2; n is 0, 1, or 2; p is 1, 2, or 3; q is 0, 1, or 2; and r is 0, 1, or 2. |
