| 发明名称 |
HETERODIMERIC FC REGIONS, BINDING MOLECULES COMPRISING SAME, AND METHODS RELATING THERETO |
| 摘要 |
The present invention features inter alia polypeptides comprising heterodimeric Fc regions. In addition, the instant invention provides methods for treating or preventing a disease or disorder in subject by administering the polypeptides of the invention to said subject. |
| 申请公布号 |
US2014341906(A1) |
申请公布日期 |
2014.11.20 |
| 申请号 |
US201214232868 |
申请日期 |
2012.07.13 |
| 申请人 |
Taylor Frederick R.;Caravella Justin A.;Lugovskoy Alexey A.;Saeed-Kothe Amna;Garber Ellen A. |
发明人 |
Taylor Frederick R.;Caravella Justin A.;Lugovskoy Alexey A.;Saeed-Kothe Amna;Garber Ellen A. |
| 分类号 |
C07K16/18 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A binding molecule comprising:
(i) at least one binding moiety, (ii) a first polypeptide chain comprising at least one Fc moiety operably linked to the N-terminus of a CL moiety (Fc-CL), and (iii) a second polypeptide chain comprising at least one Fc moiety operably linked to the N-terminus of a CH1 moiety (Fc-CH1), wherein said at least one binding moiety is linked to one or both of the polypeptide chains, and wherein said first and second polypeptide chains form a heterodimeric Fc region via CL:CH1 heterodimerization. |
| 地址 |
Milton MA US |
