| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a method of obtaining 5-aminosubstituted 1-(1-adamantyl)-3,4-dinitro-1H-pyrazoles, represented by general formula (1)where Rand Rindependently represent H, a C-Calkyl group with a branched or non-branched chain, adamantylmethyl group, benzyl group, which can have in a phenol ring from 1 to 3 substituents, selected from a halogen or C-Calkyl, or Rand Rtogether with the nitrogen atom, which they are bound to, form a 5-8-membered heterocycle, which can additionally contain one more heteroatom, selected from N and O, and the said heterocycle can be additionally substituted with C-Calkyl, C-Calkoxycarbonyl and phenylcarbonyl groups. The claimed method consists in the nucleophilic substitution of a nitrogroup in 1-(1-adamantyl)-3,4,5-trinitropyrazole with respective amines of formula HNRRin the presence of a base.EFFECT: technological method of obtaining novel compounds, which are obtained with a sufficiently high output, is developed; obtained pyrazoles potentially are the initial compounds for the synthesis of therapeutically active compounds.6 ex |
