发明名称 |
5-{8-[(3R)-4-ACETYL-3-METHYLPIPERAZIN-1-YL]-6-MORPHOLIN-4-YL-9-(2,2,2-TRIFLUOROETHYL)-9H-PURIN-2-YL}PYRIMIDINE-2- AMINE AND NOVEL CRYSTAL OF PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF, AND METHOD FOR PRODUCING SAID CRYSTAL |
摘要 |
<p>Provided are: 5-{8-[(3R)-4-acetyl-3-methylpiperazin-1-yl]- 6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2- yl}pyrimidine-2-amine which has properties suitable for the production thereof on an industrial scale, and a novel crystal of a pharmacologically acceptable salt thereof; and a method for producing the crystal. 5-{8-[(3R)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4- yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidine-2- amine and a crystal of a pharmacologically acceptable salt thereof provided by the present invention exhibit a poor hygroscopic property. Therefore, the compound and the crystal have excellent storage stability, can be synthesized suitably in a large quantity on an industrial scale, and have good physical properties for use as an active ingredient for a medicine. By employing a method for producing the crystal provided by the present invention, it becomes possible to produce a single crystal having a specific level of quality with good reproducibility and it also becomes possible to steadily supply the crystal as a crystal of an active ingredient that can be used for the production of a medicine.</p> |
申请公布号 |
WO2014185368(A1) |
申请公布日期 |
2014.11.20 |
申请号 |
WO2014JP62558 |
申请日期 |
2014.05.12 |
申请人 |
DAIICHI SANKYO COMPANY,LIMITED |
发明人 |
YOSHIDA, SHOKO;KAWAHARA, MICHIAKI |
分类号 |
C07D473/34;A61K31/5377;A61P35/00;A61P43/00 |
主分类号 |
C07D473/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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