| 摘要 |
PROBLEM TO BE SOLVED: To provide reprogramming T cells and hematopoietic cells.SOLUTION: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34hematopoietic cells, such as human CD34blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the prevent invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors. The present methods can produce iPS cells from a clinically accessible source of T cells, such as a 3 ml whole blood sample, circumventing the need of mobilization of hematopoietic cells. |
