MICRONEEDLE DEVICE INCLUDING A PEPTIDE THERAPEUTIC AGENT AND AN AMINO ACID AND METHODS OF MAKING AND USING THE SAME

摘要

A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

主权项

1. The medical device of claim 7,
wherein the molar ratio of the histidine to the peptide therapeutic agent is less than 2:1.