METHODS AND APPARATUS FOR STRATIFYING RISK OF HEART FAILURE DECOMPENSATION

摘要

Devices and methods for identifying patient at elevated risk of developing future heart failure (HF) events, such as events indicative of HF decompensation status, are described. The devices and methods can stratify the risk using sensor signals or signal metrics selected in accordance with patient chronic conditions. A medical device can receive a patient status input including at least a first and a second chronic condition indicators, sense one or more physiologic signals from the patient, and generate a plurality of signal metrics from the physiologic signals when the first chronic condition indicator and the second chronic condition indicator meets respective criterion. One or more patient-specific signal metrics can be selected from a group including the signal metrics selected for both the first and the second chronic conditions. A risk stratification algorithm can use the selected one or more patient-specific signal metrics to compute a composite risk index indicative of the probability of the patient later developing an event indicative of worsening of HF.

主权项

1. A medical device, comprising:
a signal analyzer circuit, including:
a patient status input unit configured to receive at least a first chronic condition indicator and a second chronic condition indicator of a patient, the second chronic condition indicator non-identical to the first chronic condition indicator;a signal receiver circuit configured to receive one or more physiologic signals of the patient;a signal metrics generator circuit configured to generate a plurality of signal metrics from the one or more physiologic signals, the plurality of signal metrics including a first set of one or more signal metrics when the first chronic condition indicator meets at least one first specified criterion, and a second set of signal metrics when the second chronic condition indicator meets at least one second specified criterion; anda patient-specific signal metric selector circuit configured to select from the plurality of signal metrics one or more patient-specific signal metrics selected from a group including both the first set of one or more signal metrics and the second set of one or more signal metrics; and a risk stratification circuit configured to generate a composite risk index using the selected one or more patient-specific signal metrics, the composite risk index indicative of the probability of the patient later developing an event indicative of worsening of heart failure.