Means and Methods for Assessing Gonadal Toxicity

摘要

The present invention pertains to the field of diagnostics for gonadal toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing gonadal toxicity. It also relates to a method for determining whether a compound is capable of inducing such gonadal toxicity in a subject and to a method of identifying a drug for treating gonadal toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing gonadal toxicity.

主权项

1. A method for diagnosing gonadal toxicity comprising:
(a) determining the amount of at least one biomarker selected from any one of Tables 1a, 1b, 3a, 3b, 4a, 4b, 5a, 5b, 6a or 6b in a test sample of a subject suspected to suffer from gonadal toxicity, and (b) comparing the amounts determined in step (a) to a reference, whereby gonadal toxicity is to be diagnosed.