PHOSPHORIC ACID/PHOSPHONIC ACID DERIVATIVES AND MEDICINAL USES THEREOF

摘要

The present invention relates to phosphoric acid/phosphonic acid derivatives shown by formula (I), wherein R1 and R2 represent the following structures: (Q1), or (Q2), or (Q3). Q1 represents ester derivatives of L-amino acids, wherein R3 is alkyl or cycloalkyl with 1-6 carbon atoms, and R4 is H or alkyl with 1-6 carbon atoms; Q2 represents hydroxyl substituted benzodioxane derivatives; Q3 represents hydroxyl substituted benzodioxolane derivatives; R1 and R2 are the same or different, but at least one of them is Q2 or Q3; D represents residues of pharmacologically active molecules containing a phosphoric acid/phosphonic acid group, i.e. formula (II) represents pharmacologically active molecules containing a phosphoric acid/phosphonic acid group; and when R1 and R2 are different, the configuration of the P atom connected to R1 and R2 is of R or S type.