发明名称 |
SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS |
摘要 |
Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. |
申请公布号 |
CA2912683(A1) |
申请公布日期 |
2014.11.20 |
申请号 |
CA20142912683 |
申请日期 |
2014.05.13 |
申请人 |
GLAXOSMITHKLINE LLC |
发明人 |
BLUM, CHARLES A.;OALMANN, CHRISTOPHER;SZCZEPANKIEWICZ, BRUCE G.;CALDWELL, RICHARD DANA;CASAUBON, REBECCA;WHITE, BRIAN H.;PERNI, ROBERT B.;KOPPETSCH, KARSTEN;DISCH, JEREMY S.;NG, PUI YEE;FOX, RYAN MICHAEL |
分类号 |
C07D471/04 |
主分类号 |
C07D471/04 |
代理机构 |
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