发明名称 |
Methods and apparatus for predicting protein structure |
摘要 |
The present invention relates to a method for predicting three-dimensional structure of a protein from its sequence. Three-dimensional structure may be determined by: (a) generating a multiple sequence alignment for a candidate protein having a known sequence; (b) identifying a covariance matrix between all pairs of sequence positions in the multiple sequence alignment; (c) inverting the covariance matrix and identifying predicted evolutionary constraints using a statistical model of the candidate protein; and (d) simulating folding of an extended chain structure of the candidate protein using the predicted constraints. |
申请公布号 |
AU2013259410(A1) |
申请公布日期 |
2014.11.20 |
申请号 |
AU20130259410 |
申请日期 |
2013.05.09 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;MEMORIAL SLOAN-KETTERING CANCER RESEARCH |
发明人 |
SANDER, CHRIS;MARKS, DEBORA S. |
分类号 |
G06G7/58;G06F17/30;G06F19/16;G06F19/22 |
主分类号 |
G06G7/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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