| 发明名称 |
PROCESS FOR THE PREPARATION OF TRAVOPROST |
| 摘要 |
The invention relates to a process for the preparation of travoprost of formula (I), comprising that, the compound of formula (II), is stereo selectively reduced, the resulting compound of formula (III), is if desired crystallized, the lactone group of the compound of formula (III) is reduced, the p-phenyl-benzoyl protecting group of the thus obtained compound of formula (IV), is removed, the resulting triol of formula (V), is, if desired after crystallization, transformed by Wittig reaction into the acid of formula (VI), which is then esterified.; |
| 申请公布号 |
US2014343299(A1) |
申请公布日期 |
2014.11.20 |
| 申请号 |
US201214367317 |
申请日期 |
2012.12.10 |
| 申请人 |
CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT |
发明人 |
Kardos Zsuzsanna;Kiss Tibor;Lászlofi István;Hortobágyi Irén;Bischof Zoltán;Bódis Ádám;Havasi Gábor |
| 分类号 |
C07C67/333;C07D307/937 |
主分类号 |
C07C67/333 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for the preparation of travoprost of formula (I). comprising that, the compound of formula (II). is stereoselectively reduced, the resulting compound of formula (III) is if desired crystallized, the lactone group of the compound of formula (III) is reduced, the p-phenyl-benzoyl protecting group of the thus obtained compound of formula (IV) is removed, the resulting triol of formula (V) is if desired after crystallization transformed by Wittig reaction into the acid of formula (VI), which is then esterified. |
| 地址 |
Budapest HU |
