LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE OF BODY LUMENS

摘要

A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which comprises poly(HEMA) complexed with iodine and has a substantially water-insoluble therapeutic agent dispersed therein. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.

主权项

1. A method of coating a catheter balloon comprising:
coating a catheter balloon with a coating solution comprising iodine, an organic solvent, a substantially water-insoluble therapeutic agent, and a copolymer comprising poly(HEMA) and a monomer selected from the group consisting of glycidyl methacrylate and acrylic acid; and drying the catheter balloon to form a water soluble coating on the catheter balloon, wherein the copolymer is complexed with the iodine in the water soluble coating.