发明名称 |
COMPOSITIONS AND METHODS FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS |
摘要 |
Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein. |
申请公布号 |
WO2014186729(A1) |
申请公布日期 |
2014.11.20 |
申请号 |
WO2014US38435 |
申请日期 |
2014.05.16 |
申请人 |
SURMODICS, INC. |
发明人 |
SLAGER, JORAM;SWAN, DALE, G.;DUMEZ, DARIN;VENTURA, JOSEPH;WADMAN, SHANNON;MCGONIGLE, JOSEPH, SCHMIDT;HERGENROTHER, ROBERT, W. |
分类号 |
A61L29/08;A61L29/16;A61L31/10;A61L31/16 |
主分类号 |
A61L29/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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