摘要 |
Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. |
申请人 |
GLAXOSMITHKLINE LLC |
发明人 |
BLUM, CHARLES, A.;OALMANN, CHRISTOPHER;SZCZEPANKIEWICZ, BRUCE, G.;CALDWELL, RICHARD, DANA;CASAUBON, REBECCA;WHITE, BRIAN, H.;PERNI, ROBERT, B.;KOPPETSCH, KARSTEN;DISCH, JEREMY, S.;NG, PUI, YEE;FOX, RYAN, MICHAEL |