REPROGRAMMED CELLS AND METHODS OF PRODUCTION AND USE THEREOF

摘要

The present invention relates generally to a secondary reprogramming technique and its uses. More particularly, it concerns immortalized secondary somatic cells, secondary induced pluripotent stem cells (iPSCs), secondary induced multipotent progenitor cells (iMPCs) and tertiary somatic cells derived therefrom, and methods of using these cells to assess the effects of agents on cells and for medical treatment of subjects.