| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions refers to new oxyindole derivatives of formula(I) or their pharmaceutically acceptable salts, based pharmaceutical compositions and using them for treating various disorders, which are mediated through the motilin receptor (GPR38). In general formula I, Rmeans hydrogen, C-Calkyl or C-Ccycloalkyl; Rmeans C-Calkyl or C-Ccycloalkyl; or Rand Rtogether with atoms which they are bound to, form a 3-6-merous ring, which can contain oxygen; Rand Rmean hydrogen or C-Calkyl; Rmeans hydrogen or C-Calkyl; Rand Rmean hydrogen, C-Calkyl or C-Calkoxy C-Calkyl; or Rand Rtogether with a nitrogen atom which they are bound to, form a 4-6-merous ring, which can contain nitrogen or oxygen; the 4-6-merous ring is optionally substituted by 1-4 substitutes specified in a group consisting of C-Calkyl, amino, C-Calkylamino and di(C-Calkyl)amino; A meansor, wherein p, q and r independently have the values of 0, 1 or 2; Rand Rmean hydrogen or C-Calkyl; wherein alkyl is optionally substituted by hydroxy, C-Calkyl, amino, C-Calkylamino and di(C-Calkyl)amino; or Rand Rcan be combined to form a C-C-merous ring; or Rand Rcan be independently combined with one or both Rand Rgroups to form alkylene bridges between terminal nitrogen and an alkyl part of Ror Rgroups; the bridge contains 1 to 5 carbon atoms; the above bridge is optionally substituted by 1-4 C-Calkyl groups; W means N-R, the above Rmeans hydrogen or C-Calkyl; X means C-Calkylene or C-Calkylene-K-C-Calkylene, wherein K means -O- and wherein alkylene is optionally substituted by C-Calkyl; Y means hydrogen or a 5-10-merous ring; the above ring is optionally substituted by hydroxyl, halogen, halogen C-Calkyl, C-Calkyl or C-Calkoxy; provided X means C, Y means other than hydrogen; Z means halogen or C-Calkyl; m has the value of 0, 1, 2, 3 or 4; n has the value of 0, 1 or 2.EFFECT: preparing the new oxyindole derivatives.10 cl, 15 tbl, 99 ex |
