COMBINATION THERAPY FOR TREATING HIV AND AIDS

摘要

The present invention relates to the use of a Vif inhibitor and an APOBEC3G (A3G) activator in combination to inhibit HIV infectivity in a host cell and to treat or prevent HIV infection or AIDS in a patient. In one embodiment, the present invention relates to a method for inhibiting infectivity of HIV in a host cell, which method comprises contacting a host cell comprising A3G host defense factor with a combination of antiviral-effective amounts of a Vif inhibitor and an A3G activator, thereby inhibiting infectivity of HIV in the host cell by simultaneously inhibiting Vif-dependent degradation of A3G and activating A3G deaminase activity in the host cell, where the Vif inhibitor inhibits Vif-dependent degradation of A3G by disrupting or inhibiting dimerization of Vif in the host cell, and where the A3G activator activates A3G deaminase activity by disrupting or inhibiting A3G:nucleic acid molecule interaction in the host cell.