| 摘要 |
This invention provides compounds of formulas (I), (II), (III), and (IV) as defined in the specification, and pharmaceutical compositions comprising the same, and methods of inhibiting, treating, or abrogating a poxvirus infection in a subject using the compounds or compositions. |
| 主权项 |
1. A compound of formula (I) wherein
R4, R5, R6, R7, R2′, R3′, R4′, R5′, and R6′ are independently selected from the group consisting of H, C1-C6 alkyl, halo, cyano, nitro, C1-C6 haloalkyl, ORa, SRa, NRmRn, NRaCORb, SORb, SO2Rb, CORb, COORa, aryl, heteroaryl, C3-C7 cycloalkyl, 3-7 membered heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl;Ra and Rb are each independently selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl;Rm and Rn are independently selected from the group consisting of H, C1-C6 alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl; or Rm and Rn, together with the nitrogen atom to which they are attached, form a 3-7 membered heterocycloalkyl group; andn is 1, 2, 3, 4, or 5;or a pharmaceutically acceptable salt thereof. |
