| 主权项 |
1. A compound of formula I wherein X1 and X2 are N or CH, with the proviso that X1 and X2 are not simultaneously N; X3 is a bond, C1-C4-alkylene, C1-C4-haloalkylene or CO; X4 is N or CH; X5 is C—R1 or N; R1, R2 and R3, independently of each other, are selected from hydrogen, halogen, cyano, C1-C3-alkyl, fluorinated C1-C3-alkyl, C1-C3-hydroxyalkyl, C1-C3-alkoxy and fluorinated C1-C3-alkoxy; R4 is selected from C1-C3-alkoxy; R5 is selected from hydrogen and C1-C3-alkoxy; R6 is selected from cyano and halogen; R7 is selected from hydrogen, halogen and cyano; R8 and R9, independently of each other and independently of each occurrence, are selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy, with the proviso that R8 and R9 are not halogen, C1-C4-alkoxy or C1-C4-haloalkoxy if they are bound to a carbon atom in α-position to a nitrogen ring atom; or
two non-geminal radicals R8 form together a group —(CH2)n—, where n is 1, 2, 3 or 4, where 1 or 2 hydrogen atoms in this group may be replaced a methyl group; ortwo non-geminal radicals R9 form together a group —(CH2)n—, where n is 1, 2, 3 or 4, where 1 or 2 hydrogen atoms in this group may be replaced a methyl group; each R10 is independently selected from halogen, C1-C4-alkyl and C1-C4-haloalkyl; a is 0, 1, 2, 3 or 4; b is 0, 1, 2, 3 or 4; and c is 0, 1, 2, 3 or 4; and the N-oxides, stereoisomers and pharmaceutically acceptable salts thereof, and the compound of the formula I, wherein at least one of the atoms has been re-placed by its stable, non-radioactive isotope. |
