MICROFLUIDIC PROCESSING OF LEUKOCYTES FOR MOLECULAR DIAGNOSTIC TESTING

摘要

Described herein are microfluidic devices and methods that can greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.

主权项

1. A device comprising:
(a) a channel extending from a plurality of inlets to a plurality of outlets, wherein the channel is bounded by a first wall and a second wall opposite from the first wall; and (b) an array of obstacles disposed within the channel configured to deflect particles toward the first wall when the particles are flowed in one or more fluids from the inlets to the outlets, wherein the device is configured such that at least 4 of the plurality of inlets directs multiple fluids to flow in parallel from the inlets to the outlets, and particles introduced into the channel near the second wall pass through the plurality of fluids while being deflected toward the first wall.